Assistant Professor of Biological Chemistry
We investigate the chemical biology of protein biogenesis and protein degradation, two essential events in the expression of genetic information. Our research in this area is technology and hypothesis driven, with applications to major human diseases such as tuberculosis and cancer.
Callahan B.P., Topilina, N., Stanger M., Van Roey, P., Belfort M. Structure of a catalytically competent intein caught in a redox trap with functional and biological implications. Nat. Struct. Mol. Biol. (2011) 18, 630-3.
Callahan B.P., Stanger M., Belfort M. Protease activation of split green fluorescent protein ChemBioChem (2010) 11, 2259-63.
Amitai G., Callahan B.P., Stanger M., Belfort G., Belfort M. Modulation of intein activity by its neighboring extein substrates. Proc. Natl. Acad. Sci. USA (2009) 106, 11005-10.
Callahan B.P., Yaun, Y., Wolfenden, R. The Burden Borne by Urease. J. Am. Chem. Soc. (2005) 127, 10828-9. (Highlighted in Science)
Last Updated: 9/6/12