Dr. Brian P. Callahan

Assistant Professor of Biological Chemistry

• B.S., State University of New York, Cortland, 1996
• Ph.D., University of North Carolina, Chapel Hill, 2005

Office:

Science 2 Bldg - Room 326

Phone:

607-777-3089

Fax:

607-777-4478

Email:

callahan@binghamton.edu

Web page:

http://chemiris.chem.binghamton.edu/CALLAHAN/callahan.html

Research Interests:

We investigate the chemical biology of protein biogenesis and protein degradation, two essential events in the expression of genetic information. Our research in this area is technology and hypothesis driven, with applications to major human diseases such as tuberculosis and cancer.

Recent Selected Publications

Callahan B.P., Topilina, N., Stanger M., Van Roey, P., Belfort M. Structure of a catalytically competent intein caught in a redox trap with functional and biological implications. Nat. Struct. Mol. Biol. (2011) 18, 630-3.

Callahan B.P., Stanger M., Belfort M. Protease activation of split green fluorescent protein ChemBioChem (2010) 11, 2259-63.

Amitai G., Callahan B.P., Stanger M., Belfort G., Belfort M. Modulation of intein activity by its neighboring extein substrates.  Proc. Natl. Acad. Sci. USA (2009) 106, 11005-10.

Callahan B.P., Yaun, Y., Wolfenden, R. The Burden Borne by Urease. J. Am. Chem. Soc. (2005) 127, 10828-9. (Highlighted in Science)